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Week: 575.2

Guest: Solomon Langermann, researcher, MedImmune, Gaithersburg, MD

Topic: Vaccine against urinary tract infections

Host/ Producer: Steve Girard

NEMA: A vaccine against urinary tract infections...coming up...

SPOT: NEMA...the National Emergency Medicine Association...fights our worst health enemies - heart disease, stroke, trauma. Call 800-332-6362.

NEMA: 50% of women will have a urinary tract infection by age 30...and visit the hospital or doctor for the problem nearly eight million times each year, spending 1 billion dollars. Dr. Sol Langermann of MedImmune in Maryland has developed a vaccine against the E. coli bacteria that cause UTI's....

LANGERMANN: these bacteria that cause the urinary tract infections, make an adhesion protein at the very tip of a structure called the pillus organelle. And that adhesion protein is absolutely required for the bacteria to stick to the tissue, and to cause an infection. What we have done is we've taken these adhesion proteins and used them as a vaccine, and forced the body...in this case in our mouse model, for the mice to make an antibody response against the adhesion, and that now blocks the infection from happening.

NEMA: Potentially, the vaccine could help in many areas...

LANGERMANN: this has broad applicability to a number of different bacterial infections, which also require the bacteria to attach to the host tissue before it can initiate an infection. And so, we believe that this has broad applicability to a number of bacterial diseases.

NEMA: The vaccine could be in human trials early next year. I'm Steve Girard at The Heart of the Matter.



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